منابع مشابه
Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism.
Diazoxide, a selective opener of the mitochondrial ATP-sensitive potassium channel, has been shown to elicit tolerance to ischemia in cardiac myocytes and in perfused heart. However, the mechanism of this cardioprotection is poorly understood. Because reactive oxygen species (ROS) are recognized as important intracellular signaling molecules and have been implicated in ischemic preconditioning,...
متن کاملNitroso-redox balance in the cardiovascular system.
The results with the combination therapy were markedly positive, meeting the composite end point of the trial, which included death from any cause, a first hospitalization for heart failure, and quality-oflife measures. In addition, there was an impressive reduction in the rate of death from any cause of approximately 45 percent, leading to an early termination of the study. This trial raises f...
متن کاملCysteine, Glutathione, and Thiol Redox Balance in Astrocytes
This review discusses the current understanding of cysteine and glutathione redox balance in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte activation on pathways that provide cysteine as a precursor for glutathione. The effect of the disruption of thiol-containing amino acid metabolism on the antioxidant capacity of astrocytes is also discussed.
متن کاملMitochondrial pathways, permeability transition pore, and redox signaling in cardioprotection: therapeutic implications.
Reperfusion therapy is the indispensable treatment of acute myocardial infarction (AMI) and must be applied as soon as possible to attenuate the ischemic insult. However, reperfusion is responsible for additional myocardial damage likely involving opening of the mitochondrial permeability transition pore (mPTP). A great part of reperfusion injury occurs during the first minute of reperfusion. T...
متن کاملS-glutathionylation: a redox-sensitive switch participating in nitroso-redox balance.
Cysteine side chains of proteins are being increasingly appreciated as the site of major posttranslational modifications that exert profound degrees of protein regulation. One of the consequences of tissue nitroso-redox imbalance is a process by which regulatory thiols switch from a state of physiologic regulation by S-nitrosylation to a state of dysregulated function because of oxidation. A ke...
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ژورنال
عنوان ژورنال: Basic Research in Cardiology
سال: 2013
ISSN: 0300-8428,1435-1803
DOI: 10.1007/s00395-013-0392-7